Short-Wave Infrared Confocal Fluorescence Imaging of Deep Mouse Brain with a Superconducting Nanowire Single-Photon Detector
نویسندگان
چکیده
Optical microscopy is a valuable tool for in vivo monitoring of biological structures and functions because its noninvasiveness. However, imaging deep into tissues challenging due to the scattering absorption light. Previous research has shown that two optimal wavelength windows high-resolution mouse brain are around 1300 1700 nm. one-photon fluorescence region been highly poor detection efficiency currently available detectors. To fully utilize this advantage, we demonstrated here confocal brains with an excitation 1310 nm emission within window. Fluorescence at was detected by custom-built superconducting nanowire single-photon detector (SNSPD) optimized between 1600 2000 low noise high efficiency. With PEGylated quantum dots SNSPD both positioned window tissue penetration, approximately 1.7 mm below surface brain, through entire cortical column hippocampus low-cost continuous-wave laser source power. We further discussed significance staining inhomogeneity determining depth limit imaging. Our work may motivate development long fluorescent probes, inspire innovations high-efficiency, high-gain, low-noise detectors
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ژورنال
عنوان ژورنال: ACS Photonics
سال: 2021
ISSN: ['2330-4022']
DOI: https://doi.org/10.1021/acsphotonics.1c01018